Effective and efficient platelet transfusion strategies that maintain hemostatic protection
نویسندگان
چکیده
منابع مشابه
Massive transfusion and nonsurgical hemostatic agents.
BACKGROUND Hemorrhage in trauma is a significant challenge, accounting for 30% to 40% of all fatalities, second only to central nervous system injury as a cause of death. However, hemorrhagic death is the leading preventable cause of mortality in combat casualties and typically occurs within 6 to 24 hrs of injury. In cases of severe hemorrhage, massive transfusion may be required to replace mor...
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Platelets undergo several modifications during storage that reduce their posttransfusion survival and functionality. One important feature of these changes, which are known as platelet storage lesion, is the shedding of the surface glycoproteins GPIband GPV. We recently demonstrated that tumor necrosis factorconverting enzyme (TACE/ADAM17) mediates mitochondrial injury-induced shedding of adhes...
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Prophylactic platelet concentrates transfusion represents a therapeutic choice in patients with chemotherapy-induced thrombocytopenia. This prospective, non-interventional study evaluated the effects of platelet concentrates transfusion on thromboelastometric parameters of platelet function in 36 transfusion occasions for 11 thrombocytopenic children undergoing chemotherapy. Pre- and posttransf...
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ژورنال
عنوان ژورنال: Transfusion
سال: 1998
ISSN: 0041-1132,1537-2995
DOI: 10.1046/j.1537-2995.1998.38798346628.x